Publications

         1: Kang D, Xu Q, Kirienko NV. In vitro lung epithelial cell model reveals novel roles for Pseudomonas aeruginosa siderophores.
Microbiol Spectr. 2024 Feb 5:e0369323. doi: 10.1128/spectrum.03693-23. Online ahead of print.
PMID: 38311809

2: Zhang L, Gade V, Kirienko NV. Pathogen-induced dormancy in liquid limits gastrointestinal colonization of Caenorhabditis elegans.
Virulence. 2023 Dec;14(1):2204004. doi: 10.1080/21505594.2023.2204004.
PMID: 37096826

3: Xu Q, Kang D, Meyer MD, Pennington CL, Gopal C, Schertzer JW, Kirienko NV. Cytotoxic rhamnolipid micelles drive acute virulence in Pseudomonas aeruginosa.
bioRxiv. 2023 Oct 13:2023.10.13.562257. doi: 10.1101/2023.10.13.562257. Preprint.
PMID: 37873290

4: Kirienko NV, Di YP. Editorial: Role of microbial biofilm in infections.
Front Cell Infect Microbiol. 2023 Jun 19;13:1231607. doi: 10.3389/fcimb.2023.1231607. eCollection 2023.
PMID: 37404726


5: S Cho, D Kang, NV Kirienko, B Getachew. Understanding the Relationship between Electrochemical Fouling Control and Electrode Surface Coverage (2023)
ACS ES&T Engineering 3 (11), 2062-2070 OI: 10.1021/acsestengg.3c00335


6: Younes S, Zein N, Abunasser S, Kamareddine L, Kirienko NV, Nasrallah GK. Editorial: Unconventional animal models in infectious disease research, volume II.
Front Cell Infect Microbiol. 2023 Jun 14;13:1225129. doi: 10.3389/fcimb.2023.1225129. eCollection 2023.
PMID: 37389208

7: Moreno A, Taffet A, Tjahjono E, Anderson QL, Kirienko NV. Examining Sporadic Cancer Mutations Uncovers a Set of Genes Involved in Mitochondrial Maintenance.
Genes (Basel). 2023 Apr 29;14(5):1009. doi: 10.3390/genes14051009.
PMID: 37239369

8: Tjahjono E, Kirienko DR, Kirienko NV. The emergent role of mitochondrial surveillance in cellular health.
Aging Cell. 2022 Nov;21(11):e13710. doi: 10.1111/acel.13710. Epub 2022 Sep 11.
PMID: 36088658


9: Zhang L, Tan FC, Strasfeld L, Hakki M, Kirienko NV. Long-Term Dominance of
Carbapenem-Non-Susceptible <i>Pseudomonas aeruginosa</i> ST111 in Hematologic
Malignancy Patients and Hematopoietic Cell Transplant Recipients. Front Cell
Infect Microbiol. 2022 Jun 16;12:904602. doi: 10.3389/fcimb.2022.904602. PMID:
35782141; PMCID: PMC9244782.

10: Panina SB, Pei J, Baran N, Tjahjono E, Patel S, Alatrash G, Konoplev S,
Stolbov LA, Poroikov VV, Konopleva M, Kirienko NV. Novel mitochondria-targeting
compounds selectively kill human leukemia cells. Leukemia. 2022 Jun 7. doi:
10.1038/s41375-022-01614-0. Epub ahead of print. PMID: 35672446.

11: Tjahjono E, Revtovich AV, Kirienko NV. Box C/D small nucleolar
ribonucleoproteins regulate mitochondrial surveillance and innate immunity. PLoS
Genet. 2022 Mar 11;18(3):e1010103. doi: 10.1371/journal.pgen.1010103. PMID:
35275914; PMCID: PMC8942280.

12: Tjahjono E, Pei J, Revtovich AV, Liu TE, Swadi A, Hancu MC, Tolar JG,
Kirienko NV. Mitochondria-affecting small molecules ameliorate proteostasis
defects associated with neurodegenerative diseases. Sci Rep. 2021 Sep
6;11(1):17733. doi: 10.1038/s41598-021-97148-z. PMID: 34489512; PMCID:
PMC8421394.

13: Tjahjono E, Revtovich AV, Kirienko NV. Imaging and Fluorescence
Quantification in <i>Caenorhabditis elegans</i>with Flow Vermimetry and
Automated Microscopy. Bio Protoc. 2021 May 20;11(10):e4024. doi:
10.21769/BioProtoc.4024. PMID: 34150931; PMCID: PMC8187112.

14: Kang D, Revtovich AV, Deyanov AE, Kirienko NV. Pyoverdine Inhibitors and
Gallium Nitrate Synergistically Affect Pseudomonas aeruginosa. mSphere. 2021 Jun
16;6(3):e0040121. doi: 10.1128/mSphere.00401-21. Epub ahead of print. PMID:
34133200; PMCID: PMC8265654.

15: Revtovich AV, Tjahjono E, Singh KV, Hanson BM, Murray BE, Kirienko NV.
Development and Characterization of High-Throughput <i>Caenorhabditis
elegans</i> - <i>Enterococcus faecium</i> Infection Model. Front Cell Infect
Microbiol. 2021 Apr 29;11:667327. doi: 10.3389/fcimb.2021.667327. PMID:
33996637; PMCID: PMC8116795.

16: Martineau CN, Kirienko NV, Pujol N. Innate immunity in C. elegans. Curr Top
Dev Biol. 2021;144:309-351. doi: 10.1016/bs.ctdb.2020.12.007. Epub 2021 Mar 4.
PMID: 33992157; PMCID: PMC9175240.

17: Kang D, Zhang L, Kirienko NV. High-Throughput Approaches for the
Identification of <i>Pseudomonas aeruginosa</i> Antivirulents. mBio. 2021 May
4;12(3):e02240-20. doi: 10.1128/mBio.02240-20. PMID: 33947765; PMCID:
PMC8262948.

18: Panina SB, Pei J, Kirienko NV. Mitochondrial metabolism as a target for
acute myeloid leukemia treatment. Cancer Metab. 2021 Apr 21;9(1):17. doi:
10.1186/s40170-021-00253-w. PMID: 33883040; PMCID: PMC8058979.

19: Rosiana S, Zhang L, Kim GH, Revtovich AV, Uthayakumar D, Sukumaran A,
Geddes-McAlister J, Kirienko NV, Shapiro RS. Comprehensive genetic analysis of
adhesin proteins and their role in virulence of Candida albicans. Genetics. 2021
Feb 9;217(2):iyab003. doi: 10.1093/genetics/iyab003. PMID: 33724419; PMCID:
PMC8045720.

20: Hummell NA, Revtovich AV, Kirienko NV. Novel Immune Modulators Enhance
<i>Caenorhabditis elegans</i> Resistance to Multiple Pathogens. mSphere. 2021
Jan 6;6(1):e00950-20. doi: 10.1128/mSphere.00950-20. PMID: 33408224; PMCID:
PMC7845594.

21: Kang D, Kirienko NV. An In Vitro Cell Culture Model for Pyoverdine-Mediated
Virulence. Pathogens. 2020 Dec 24;10(1):9. doi: 10.3390/pathogens10010009. PMID:
33374230; PMCID: PMC7824568.

22: Kim GH, Rosiana S, Kirienko NV, Shapiro RS. A Simple Nematode Infection
Model for Studying Candida albicans Pathogenesis. Curr Protoc Microbiol. 2020
Dec;59(1):e114. doi: 10.1002/cpmc.114. PMID: 32975912.

23: Wang X, Kleerekoper Q, Revtovich AV, Kang D, Kirienko NV. Identification and
validation of a novel anti-virulent that binds to pyoverdine and inhibits its
function. Virulence. 2020 Dec;11(1):1293-1309. doi:
10.1080/21505594.2020.1819144. PMID: 32962519; PMCID: PMC7549923.

24: Tjahjono E, McAnena AP, Kirienko NV. The evolutionarily conserved ESRE
stress response network is activated by ROS and mitochondrial damage. BMC Biol.
2020 Jun 29;18(1):74. doi: 10.1186/s12915-020-00812-5. PMID: 32600387; PMCID:
PMC7322875.

25: Pei J, Panina SB, Kirienko NV. An Automated Differential Nuclear Staining
Assay for Accurate Determination of Mitocan Cytotoxicity. J Vis Exp. 2020 May
12;(159):10.3791/61295. doi: 10.3791/61295. PMID: 32478749; PMCID: PMC8310432.

26: Panina SB, Pei J, Baran N, Konopleva M, Kirienko NV. Utilizing Synergistic
Potential of Mitochondria-Targeting Drugs for Leukemia Therapy. Front Oncol.
2020 Apr 3;10:435. doi: 10.3389/fonc.2020.00435. PMID: 32318340; PMCID:
PMC7146088.

27: Hummell NA, Kirienko NV. Repurposing bioactive compounds for treating
multidrug-resistant pathogens. J Med Microbiol. 2020 Jun;69(6):881-894. doi:
10.1099/jmm.0.001172. PMID: 32163353; PMCID: PMC7363280.

28: Kirienko NV, Rahme L, Cho YH. Editorial: Beyond Antimicrobials: Non-
traditional Approaches to Combating Multidrug-Resistant Bacteria. Front Cell
Infect Microbiol. 2019 Oct 11;9:343. doi: 10.3389/fcimb.2019.00343. PMID:
31681623; PMCID: PMC6797549.

29: Kang D, Revtovich AV, Chen Q, Shah KN, Cannon CL, Kirienko NV. Pyoverdine-
Dependent Virulence of <i>Pseudomonas aeruginosa</i> Isolates From Cystic
Fibrosis Patients. Front Microbiol. 2019 Sep 6;10:2048. doi:
10.3389/fmicb.2019.02048. PMID: 31551982; PMCID: PMC6743535.

30: Panina SB, Baran N, Brasil da Costa FH, Konopleva M, Kirienko NV. A
mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic
drugs. Cell Death Dis. 2019 Aug 13;10(8):617. doi: 10.1038/s41419-019-1851-3.
PMID: 31409768; PMCID: PMC6692368.

31: Revtovich AV, Lee R, Kirienko NV. Interplay between mitochondria and diet
mediates pathogen and stress resistance in Caenorhabditis elegans. PLoS Genet.
2019 Mar 13;15(3):e1008011. doi: 10.1371/journal.pgen.1008011. PMID: 30865620;
PMCID: PMC6415812.

32: Kirienko DR, Kang D, Kirienko NV. Novel Pyoverdine Inhibitors Mitigate
<i>Pseudomonas aeruginosa</i> Pathogenesis. Front Microbiol. 2019 Jan 9;9:3317.
doi: 10.3389/fmicb.2018.03317. PMID: 30687293; PMCID: PMC6333909.

33: Anderson QL, Revtovich AV, Kirienko NV. A High-throughput, High-content,
Liquid-based C. elegans Pathosystem. J Vis Exp. 2018 Jul 1;(137):58068. doi:
10.3791/58068. PMID: 30010665; PMCID: PMC6102028.

34: Kang D, Kirienko NV. Interdependence between iron acquisition and biofilm
formation in Pseudomonas aeruginosa. J Microbiol. 2018 Jul;56(7):449-457. doi:
10.1007/s12275-018-8114-3. Epub 2018 Jun 14. PMID: 29948830; PMCID: PMC6221862.

35: Kang D, Kirienko DR, Webster P, Fisher AL, Kirienko NV. Pyoverdine, a
siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes
iron, and activates a distinct host response. Virulence. 2018 Dec
31;9(1):804-817. doi: 10.1080/21505594.2018.1449508. PMID: 29532717; PMCID:
PMC5955448.

36: Kang D, Turner KE, Kirienko NV. PqsA Promotes Pyoverdine Production via
Biofilm Formation. Pathogens. 2017 Dec 25;7(1):3. doi: 10.3390/pathogens7010003.
PMID: 29295589; PMCID: PMC5874729.

37: Shapiro RS, Chavez A, Porter CBM, Hamblin M, Kaas CS, DiCarlo JE, Zeng G, Xu
X, Revtovich AV, Kirienko NV, Wang Y, Church GM, Collins JJ. A CRISPR-Cas9-based
gene drive platform for genetic interaction analysis in Candida albicans. Nat
Microbiol. 2018 Jan;3(1):73-82. doi: 10.1038/s41564-017-0043-0. Epub 2017 Oct
23. PMID: 29062088; PMCID: PMC5832965.

38: Kang D, Kirienko NV. High-Throughput Genetic Screen Reveals that Early
Attachment and Biofilm Formation Are Necessary for Full Pyoverdine Production by
<i>Pseudomonas aeruginosa</i>. Front Microbiol. 2017 Sep 5;8:1707. doi:
10.3389/fmicb.2017.01707. PMID: 28928729; PMCID: PMC5591869.

39: Tjahjono E, Kirienko NV. A conserved mitochondrial surveillance pathway is
required for defense against Pseudomonas aeruginosa. PLoS Genet. 2017 Jun
29;13(6):e1006876. doi: 10.1371/journal.pgen.1006876. PMID: 28662060; PMCID:
PMC5510899.

40: Kirienko DR, Revtovich AV, Kirienko NV. A High-Content, Phenotypic Screen
Identifies Fluorouridine as an Inhibitor of Pyoverdine Biosynthesis and
Pseudomonas aeruginosa Virulence. mSphere. 2016 Aug 24;1(4):e00217-16. doi:
10.1128/mSphere.00217-16. PMID: 27579370; PMCID: PMC4999921.

41: Kirienko NV, Ausubel FM, Ruvkun G. Mitophagy confers resistance to
siderophore-mediated killing by Pseudomonas aeruginosa. Proc Natl Acad Sci U S
A. 2015 Feb 10;112(6):1821-6. doi: 10.1073/pnas.1424954112. Epub 2015 Jan 26.
PMID: 25624506; PMCID: PMC4330731.

42: Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM.
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen
infection. Nature. 2014 Dec 18;516(7531):414-7. doi: 10.1038/nature13818. Epub
2014 Sep 28. PMID: 25274306; PMCID: PMC4270954.

43: Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR. Pseudomonas aeruginosa
PA14 pathogenesis in Caenorhabditis elegans. Methods Mol Biol. 2014;1149:653-69.
doi: 10.1007/978-1-4939-0473-0_50. PMID: 24818940.

44: Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV. High-throughput
screening for novel anti-infectives using a C. elegans pathogenesis model. Curr
Protoc Chem Biol. 2014 Mar 14;6(1):25-37. doi: 10.1002/9780470559277.ch130160.
PMID: 24652621; PMCID: PMC4021578.

45: Kuzmanov A, Karina EI, Kirienko NV, Fay DS. The conserved PBAF nucleosome-
remodeling complex mediates the response to stress in Caenorhabditis elegans.
Mol Cell Biol. 2014 Mar;34(6):1121-35. doi: 10.1128/MCB.01502-13. Epub 2014 Jan
13. PMID: 24421384; PMCID: PMC3958046.

46: Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman
SK, Kingston RE, Dillin A, Asara JM, Ruvkun G. DAF-16 employs the chromatin
remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol.
2013 May;15(5):491-501. doi: 10.1038/ncb2720. Epub 2013 Apr 21. PMID: 23604319;
PMCID: PMC3748955.

47: Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM.
Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing
a hypoxic response and death. Cell Host Microbe. 2013 Apr 17;13(4):406-16. doi:
10.1016/j.chom.2013.03.003. PMID: 23601103; PMCID: PMC3641844.

48: Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL,
Ausubel FM. Stimulation of host immune defenses by a small molecule protects C.
elegans from bacterial infection. PLoS Genet. 2012;8(6):e1002733. doi:
10.1371/journal.pgen.1002733. Epub 2012 Jun 14. PMID: 22719261; PMCID:
PMC3375230.

49: McEwan DL, Kirienko NV, Ausubel FM. Host translational inhibition by
Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis
elegans. Cell Host Microbe. 2012 Apr 19;11(4):364-74. doi:
10.1016/j.chom.2012.02.007. PMID: 22520464; PMCID: PMC3334877.

50: Sait M, Kamneva OK, Fay DS, Kirienko NV, Polek J, Shirasu-Hiza MM, Ward NL.
Genomic and Experimental Evidence Suggests that Verrucomicrobium spinosum
Interacts with Eukaryotes. Front Microbiol. 2011 Oct 18;2:211. doi:
10.3389/fmicb.2011.00211. PMID: 22022322; PMCID: PMC3196152.

51: Kirienko NV, Mani K, Fay DS. Cancer models in Caenorhabditis elegans. Dev
Dyn. 2010 May;239(5):1413-48. doi: 10.1002/dvdy.22247. PMID: 20175192; PMCID:
PMC4098942.

52: Kirienko NV, Fay DS. SLR-2 and JMJC-1 regulate an evolutionarily conserved
stress-response network. EMBO J. 2010 Feb 17;29(4):727-39. doi:
10.1038/emboj.2009.387. Epub 2010 Jan 7. PMID: 20057358; PMCID: PMC2829162.

53: Barends TR, Hartmann E, Griese JJ, Beitlich T, Kirienko NV, Ryjenkov DA,
Reinstein J, Shoeman RL, Gomelsky M, Schlichting I. Structure and mechanism of a
bacterial light-regulated cyclic nucleotide phosphodiesterase. Nature. 2009 Jun
18;459(7249):1015-8. doi: 10.1038/nature07966. PMID: 19536266.

54: Tyagi A, Penzkofer A, Griese J, Schlichting I, Kirienko N, Gomelsky M#. (2008)
Photodynamics of blue-light-regulated phosphodiesterase BlrP1 protein from
Klebsiella pneumoniae and its photoreceptor BLUF domain.
Chemical Physics, 354: 130-141. doi:10.1016/j.chemphys.2008.10.003

55: Kirienko NV, McEnerney JD, Fay DS. Coordinated regulation of intestinal
functions in C. elegans by LIN-35/Rb and SLR-2. PLoS Genet. 2008 Apr
25;4(4):e1000059. doi: 10.1371/journal.pgen.1000059. PMID: 18437219; PMCID:
PMC2312330.

56: Kirienko NV, Fay DS. Transcriptome profiling of the C. elegans Rb ortholog
reveals diverse developmental roles. Dev Biol. 2007 May 15;305(2):674-84. doi:
10.1016/j.ydbio.2007.02.021. Epub 2007 Feb 21. PMID: 17368442; PMCID:
PMC2680605.

57: Bender AM, Kirienko NV, Olson SK, Esko JD, Fay DS. lin-35/Rb and the CoREST
ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development
in C. elegans. Dev Biol. 2007 Feb 15;302(2):448-62. doi:
10.1016/j.ydbio.2006.09.051. Epub 2006 Oct 5. PMID: 17070797; PMCID: PMC1933485.

58: Kirienko NV, Lepikhov KA, Zheleznaya LA, Matvienko NI. Significance of codon
usage and irregularities of rare codon distribution in genes for expression of
BspLU11III methyltransferases. Biochemistry (Mosc). 2004 May;69(5):527-35. doi:
10.1023/b:biry.0000029851.96180.92. PMID: 15193127.