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Kirienko Lab     - we work with worms -


Contact Information

Skype: kirienkolab
Email: kirienko@rice.edu
Phone: 713-348-2581
Office: GRB Hall, W200N


         The evolutionarily conserved ESRE stress response network is activated by ROS and mitochondrial damage.
Tjahjono E, McAnena AP, Kirienko NV.
BMC Biol. 2020 Jun 29;18(1):74. doi: 10.1186/s12915-020-00812-5.
PMID: 32600387 Free PMC article.

An Automated Differential Nuclear Staining Assay for Accurate Determination of Mitocan Cytotoxicity.
Pei J, Panina SB, Kirienko NV.
J Vis Exp. 2020 May 12;(159). doi: 10.3791/61295.
PMID: 32478749

Utilizing Synergistic Potential of Mitochondria-Targeting Drugs for Leukemia Therapy.
Panina SB, Pei J, Baran N, Konopleva M, Kirienko NV.
Front Oncol. 2020 Apr 3;10:435. doi: 10.3389/fonc.2020.00435. eCollection 2020.
PMID: 32318340 Free PMC article.

Repurposing bioactive compounds for treating multidrug-resistant pathogens.
Hummell NA, Kirienko NV.
J Med Microbiol. 2020 Jun;69(6):881-894. doi: 10.1099/jmm.0.001172.
PMID: 32163353 Free PMC article.

Editorial: Beyond Antimicrobials: Non-traditional Approaches to Combating Multidrug-Resistant Bacteria.
Kirienko NV, Rahme L, Cho YH.
Front Cell Infect Microbiol. 2019 Oct 11;9:343. doi: 10.3389/fcimb.2019.00343. eCollection 2019.
PMID: 31681623 Free PMC article. No abstract available.

Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients.
Kang D, Revtovich AV, Chen Q, Shah KN, Cannon CL, Kirienko NV.
Front Microbiol. 2019 Sep 6;10:2048. doi: 10.3389/fmicb.2019.02048. eCollection 2019.
PMID: 31551982 Free PMC Article

A mechanism for increased sensitivity of acute myeloid leukemia to mitotoxic drugs.
Panina SB, Baran N, Brasil da Costa FH, Konopleva M, Kirienko NV.
Cell Death Dis. 2019 Aug 13;10(8):617. doi: 10.1038/s41419-019-1851-3.
PMID: 31409768 Free PMC Article

Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans.
Revtovich AV, Lee R, Kirienko NV.
PLoS Genet. 2019 Mar 13;15(3):e1008011. doi: 10.1371/journal.pgen.1008011. eCollection 2019 Mar.
PMID: 30865620 Free Article

Novel Pyoverdine Inhibitors Mitigate Pseudomonas aeruginosa Pathogenesis.
Kirienko DR, Kang D, Kirienko NV.
Front Microbiol. 2019 Jan 9;9:3317. doi: 10.3389/fmicb.2018.03317. eCollection 2018.
PMID: 30687293 Free PMC Article

A High-throughput, High-content, Liquid-based C. elegans Pathosystem.
Anderson QL, Revtovich AV, Kirienko NV.
J Vis Exp. 2018 Jul 1;(137). doi: 10.3791/58068.
PMID: 30010665

Interdependence between iron acquisition and biofilm formation in Pseudomonas
Kang D, Kirienko NV.
J Microbiol. 2018 Jul;56(7):449-457. doi: 10.1007/s12275-018-8114-3. Epub
2018 Jun 14. Review.
PMID: 29948830

Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response.
Kang D, Kirienko DR, Webster P, Fisher AL, Kirienko NV.
Virulence. 2018 Dec 31;9(1):804-817. doi: 10.1080/21505594.2018.1449508.
PMID: 29532717 Free PMC Article
Similar articles

PqsA Promotes Pyoverdine Production via Biofilm Formation.
Kang D, Turner KE, Kirienko NV.
Pathogens. 2017 Dec 25;7(1). pii: E3. doi: 10.3390/pathogens7010003.
PMID: 29295589 Free Article

Shapiro RS, Chavez A, Porter CBM, Hamblin M, Kaas CS, DiCarlo JE, Zeng G, Xu
X, Revtovich AV, Kirienko NV, Wang Y, Church GM, Collins JJ.
Nat Microbiol. 2017 Oct 23. doi: 10.1038/s41564-017-0043-0. [Epub ahead of
PMID: 29062088

High-Throughput Genetic Screen Reveals that Early Attachment and Biofilm
Formation Are Necessary for Full Pyoverdine Production by Pseudomonas
Kang D, Kirienko NV.
Front Microbiol. 2017 Sep 5;8:1707. doi: 10.3389/fmicb.2017.01707.
eCollection 2017.
PMID: 28928729 Free PMC Article

A conserved mitochondrial surveillance pathway is required for defense
against Pseudomonas aeruginosa.
Tjahjono E, Kirienko NV.
PLoS Genet. 2017 Jun 29;13(6):e1006876. doi: 10.1371/journal.pgen.1006876.
eCollection 2017 Jun.
PMID: 28662060 Free PMC Article

A High-Content, Phenotypic Screen Identifies Fluorouridine as an Inhibitor of
Pyoverdine Biosynthesis and Pseudomonas aeruginosa Virulence.
Kirienko DR, Revtovich AV, Kirienko NV.
mSphere. 2016 Aug 24;1(4). pii: e00217-16. doi: 10.1128/mSphere.00217-16.
eCollection 2016 Jul-Aug.
PMID: 27579370 Free PMC Article

Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas
Kirienko NV, Ausubel FM, Ruvkun G.
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1821-6. doi:
10.1073/pnas.1424954112. Epub 2015 Jan 26.
PMID: 25624506 Free PMC Article

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen
Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM.
Nature. 2014 Dec 18;516(7531):414-7. doi: 10.1038/nature13818. Epub 2014 Sep
PMID: 25274306 Free PMC Article

Pseudomonas aeruginosa PA14 pathogenesis in Caenorhabditis elegans.
Kirienko NV, Cezairliyan BO, Ausubel FM, Powell JR.
Methods Mol Biol. 2014;1149:653-69. doi: 10.1007/978-1-4939-0473-0_50.
PMID: 24818940

High-throughput screening for novel anti-infectives using a C. elegans
pathogenesis model.
Conery AL, Larkins-Ford J, Ausubel FM, Kirienko NV.
Curr Protoc Chem Biol. 2014 Mar 14;6(1):25-37. doi:
PMID: 24652621 Free PMC Article

The conserved PBAF nucleosome-remodeling complex mediates the response to
stress in Caenorhabditis elegans.
Kuzmanov A, Karina EI, Kirienko NV, Fay DS.
Mol Cell Biol. 2014 Mar;34(6):1121-35. doi: 10.1128/MCB.01502-13. Epub 2014
Jan 13.
PMID: 24421384 Free PMC Article

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance
and longevity.
Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman
SK, Kingston RE, Dillin A, Asara JM, Ruvkun G.
Nat Cell Biol. 2013 May;15(5):491-501. doi: 10.1038/ncb2720. Epub 2013 Apr
PMID: 23604319 Free PMC Article

Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis,
causing a hypoxic response and death.
Kirienko NV, Kirienko DR, Larkins-Ford J, Wahlby C, Ruvkun G, Ausubel FM.
Cell Host Microbe. 2013 Apr 17;13(4):406-16. doi: 10.1016/j.chom.2013.03.003.
PMID: 23601103 Free PMC Article

Stimulation of host immune defenses by a small molecule protects C. elegans
from bacterial infection.
Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel
PLoS Genet. 2012;8(6):e1002733. doi: 10.1371/journal.pgen.1002733. Epub 2012
Jun 14.
PMID: 22719261 Free PMC Article

Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers
an immune response in Caenorhabditis elegans.
McEwan DL, Kirienko NV, Ausubel FM.
Cell Host Microbe. 2012 Apr 19;11(4):364-74. doi: 10.1016/j.chom.2012.02.007.
PMID: 22520464 Free PMC Article

Genomic and Experimental Evidence Suggests that Verrucomicrobium spinosum
Interacts with Eukaryotes.
Sait M, Kamneva OK, Fay DS, Kirienko NV, Polek J, Shirasu-Hiza MM, Ward NL.
Front Microbiol. 2011 Oct 18;2:211. doi: 10.3389/fmicb.2011.00211.
eCollection 2011.
PMID: 22022322 Free PMC Article

Cancer models in Caenorhabditis elegans.
Kirienko NV, Mani K, Fay DS.
Dev Dyn. 2010 May;239(5):1413-48. doi: 10.1002/dvdy.22247. Review.
PMID: 20175192 Free PMC Article

SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response
Kirienko NV, Fay DS.
EMBO J. 2010 Feb 17;29(4):727-39. doi: 10.1038/emboj.2009.387. Epub 2010 Jan
PMID: 20057358 Free PMC Article

Structure and mechanism of a bacterial light-regulated cyclic nucleotide
Barends TR, Hartmann E, Griese JJ, Beitlich T, Kirienko NV, Ryjenkov DA,
Reinstein J, Shoeman RL, Gomelsky M, Schlichting I.
Nature. 2009 Jun 18;459(7249):1015-8. doi: 10.1038/nature07966.
PMID: 19536266

Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and
Kirienko NV, McEnerney JD, Fay DS.
PLoS Genet. 2008 Apr 25;4(4):e1000059. doi: 10.1371/journal.pgen.1000059.
PMID: 18437219 Free PMC Article

Transcriptome profiling of the C. elegans Rb ortholog reveals diverse
developmental roles.
Kirienko NV, Fay DS.
Dev Biol. 2007 May 15;305(2):674-84. Epub 2007 Feb 21.
PMID: 17368442 Free PMC Article

lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval
morphogenesis and gonad development in C. elegans.
Bender AM, Kirienko NV, Olson SK, Esko JD, Fay DS.
Dev Biol. 2007 Feb 15;302(2):448-62. Epub 2006 Oct 5.
PMID: 17070797 Free PMC Article

Significance of codon usage and irregularities of rare codon distribution in
genes for expression of BspLU11III methyltransferases.
Kirienko NV, Lepikhov KA, Zheleznaya LA, Matvienko NI.
Biochemistry (Mosc). 2004 May;69(5):527-35.
PMID: 15193127